DRESS syndrome
Phenytoin is metabolized primarily in the liver by CYP2C9 and CYP2C19 to 5- (4-hydroxyphenyl)-5-phenylhydantoin, which is glucuronidated and excreted
Amiodarone inhibits the metabolism of phenytoin and can increase plasma phenytoin levels threefold [ 54, 55] Antihypertensive Agents
However, fewer studies have shown how these alterations in metabolism affect drug response, resistance and ADRs
By plotting the rate of administration of phenytoin acid against the apparent plasma clearance rate, we estimated the maximum rate of metabolism and the serum concentration at which the rate of metabolism was one half the maximum rate for
Vitamin D: Phenytoin interferes with vitamin D metabolism and osteomalacia may result; may need to supplement with vitamin D Tube feedings: Tube feedings decrease phenytoin absorption
Long-term phenytoin use with warfarin can decrease the INR since it is a CYP inducer
At high phenytoin concentrations, where CYP2C19 contributes to phenytoin metabolism more than at low concentrations, topiramate may inhibit the CYP2C19
The half-life for conversion of fosphenytoin to phenytoin ranges from 7-15 minutes
This medicine is an anticonvulsant that works in the brain tissue to stop seizures
Two types of alcohol-medication interactions exist: (1) pharmacokinetic interactions, in which alcohol interferes with the metabolism of the medication, and (2) pharmacodynamic interactions, in which alcohol enhances the This study aims to assess the catalytic activities of wild-type (CYP2C9*1) and 36 CYP2C9 allelic variants found in the Chinese population toward phenytoin (PHT) in vitro
In incubations with 100 microM phenytoin, PMA-stimulated neutrophils from six human subjects produced p-, m-, and o-isomers of 5-(hydroxyphenyl)-5-phenylhydantoin
• The optimal dosage of phenytoin can be accurately determined by a pharmacokinetic method
Roles of cytochrome P4502C9 and cytochrome P4502C19 in the stereoselective metabolism of phenytoin to its major metabolite Drug Metab Dispos